Effector-Independent Mechanisms Apoptosis of Tumor Cells via Immune TCR Mimic Monoclonal Antibodies Induce Weidanz
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Monoclonal antibodies for the therapy of cancer
Introduction The introduction of monoclonal antibodies for the treatment of cancer Monoclonal Antibodies (mAbs) comprise a class of therapeutic biologics that has been increasingly used over the last decades. The concept of using antibodies to selectively target tumors was proposed by Paul Ehrlich over a century ago [1]. The development of the hybridoma technology in 1975 enabled the production...
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Natural killer (NK) cells play a pivotal role in the first line of defense against cancer. NK cells that are deficient in CD3 and a clonal T cell receptor (TCR) can be subdivided into two major subtypes, CD56dimCD16+ cytotoxic and CD56brightCD16- immunoregulatory NK cells. Cytotoxic NK cells not only directly kill tumor cells without previous stimulation by cytotoxic effector molecules, such as...
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Monoclonal antibodies (mAbs) are increasingly being used to treat cancer. In response to mAb therapy, we have identified macrophages in the liver as major effector cells removing circulating tumor cells via antibody-dependent phagocytosis, an immune cell-mediated process that prevented liver metastasis. This discovery extends our understanding of the mechanisms of mAb therapy, and may help to o...
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Clinical responses to anti-tumor monoclonal antibody (mAb) treatment have been regarded for many years only as a consequence of the ability of mAbs to destroy tumor cells by innate immune effector mechanisms. More recently, it has also been shown that anti-tumor antibodies can induce a long-lasting anti-tumor adaptive immunity, likely responsible for durable clinical responses, a phenomenon tha...
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تاریخ انتشار 2011